Possible Interaction: Antioxidants and Emodin

“Pretreatment with the antioxidant NAC diminished apoptosis and p53 overexpression induced by emodin.”

“ Emodin improves antioxidant function , relieves oxidative stress and inflammation cytokines via Nrf2/Keap1-ARE and NF-κB pathways, and protects against the adverse effects induced by CyHV-3.”

“Moreover, emodin enhanced serum immune and antioxidant enzyme activity, increased metabolic activity through PPARs signaling, increased antioxidant capacity through PPARs and Nrf2-Keap1 signaling based on the transcriptional expression of specific genes.”

“Quantitative RT-PCR results illustrated that emodin up-regulated transcription of DAF-16 target genes which express antioxidants to promote antioxidant capacity and lifespan of worms.”

“Using Caenorhabditis elegans (C. elegans) as an animal model, we found emodin could extend lifespan of worms and improve their antioxidant capacity.”

“Besides, … antioxidant enzyme genes … regulated by emodin exposure for 24 h. During low concentrations of exposure, mRNA levels of Cu‐Zn SOD in the cells treated with 0.….20 &mgr;g/ml, CAT, NOX2 and Nrf2 in the cells treated with 1 &mgr;g/ml were sharply increased, respectively.”

“…,emodin abrogated DEP-induced increase of heart tissue levels of interleukin 1β (n=8, P<0.01) and … factor α (n=8, P<0.05), and significantly mitigated the change of the activities of antioxidant enzymes superoxide dismutase (n=8, P<0.… glutathione reductase (n=8, P<0.05).”

“Therefore, dietary supplementation with 60 mg/kg emodin or 500 mg/kg vitamin E can improve HSP70 mRNA levels and antioxidant capabilities, resistance to crowding stress, and growth in M. amblycephala.”

“ EMD treatment at 3 daily doses (0.6 or 1.2 mmol/kg) could enhance myocardial mitochondrial ATP generation capacity and antioxidant components in both male and female rat hearts, but it only significantly protected against I-R injury in female hearts.”