Possible Interaction: Antioxidants and Ellagic Acid

“ EA also inhibits hepatic stellate cells and mast cells activation, the proliferation of transformed cells, as well as viral replication by increasing antioxidant response , induction of apoptosis, downregulation of genes involved in cell cycle and angiogenesis, and stimulation of cellular immune response.”

“Besides, EA significantly improved nitric oxide synthase activity, antioxidant capacity and markers of endothelial dysfunction in plasma.”

“Measurement of antioxidant enzymes such as superoxide dismutase (SOD), catalase, glutathione peroxidase (GSH-Px) and glutathione reductase (GR) in tumor cells showed decrease after treatment with EA and radiation in vivo.”

“ EA induced the level of expression and activation of nuclear factor-erythroid 2-related factor (Nrf2) and its target cytoprotective and antioxidant genes , heme oxygenase-1 (HO-1) and quinone oxidoreductase 1 (NQO1).”

“These findings reveal a potential inhibitory role of ellagic acid antioxidant on OAT1 and OAT3 expression and thus explains its nephroprotective effect against cisplatin nephrotoxicity.”

“The present study suggest that EA can effectively enhance the haematological values, immune response, antioxidant capacity , and disease resistance in rainbow trout.”

“The encapsulation of EA significantly prevented its degradation and improved its antioxidant properties in in vitro conditions.”

“ABSTRACT Ellagic acid EA ) has significant protective and antioxidant effects on several tissues.”

“Results showed that administration of EA combined with MG significantly elevated the levels of enzymatic antioxidants and decreased lipid peroxidation compared with MG treatment alone.”

“The findings of this study demonstrated that ellagic acid had a positive effect on the haematological parameters, the immune response and the antioxidant enzyme activities of the fish.”

“Oral supplementation of EA significantly influences maintenance of antioxidant status and transcriptional inactivation of ODC expression, reducing ACF proliferation and/or progression, thus signifying the chemopreventive efficacy of EA against CRC.”