Possible Interaction: Antioxidants and Ebselen

“We conclude by showing that ebselen is capable of inducing transcription of the anti-oxidant response element (ARE) and postulate that ebselen may act both by the transcriptional upregulation of anti-oxidant proteins , and directly as an anti-oxidant in its own right.”

“In VSMCs, PDGF dose-dependently increased migration … 10 ng/mL. Pretreatment with the antioxidant N-acetyl-cysteine, … glutathione peroxidase mimetic ebselen significantly attenuated migration (PDGF alone, 5.0 ± 1.1-fold; NAC, 1.8 ± 0.… migration; and ebselen, 2.0 ± 0.5-fold migration), as did overexpression of catalase.”

“ Antioxidants inhibited proliferation: vitamin E succinate (100 microM) by 91%, ebselen (30 microM) by 81%, and N-acetylcysteine (30 mM) by 95%.”

“ Ebselen may be protective against sciatic nerve I/R injury via antioxidant and antiapoptotic activities at a 15 mg/kg dose, conversely higher doses may cause detrimental effects.”

“In conclusion, antioxidant protection by ebselen attenuated I/R injury of neurons and pancreatic β-cells and prevented subsequent impairment of glucose regulation that could lead to diabetes and Alzheimer's disease.”

“Reactive oxygen species (ROS) is likely to be involved, because treatment with antioxidants N‐acetylcysteine (NAC) and ebselen inhibits the leishmanicidal effect of macrophages under hypoxia.”

“We also observed that Nrf2 activation by ebselen increased the expression of phase II antioxidant genes , including heme oxygenase (HO-1), NAD(P)H:quinine oxidoreductase, and gamma-glutamylcysteine synthetase (gamma-GCS).”

“The antioxidant ebselen markedly elevated the nuclear Ref-1 expression and Egr-1/DNA binding, and decreased the ulcerogenic effect of cysteamine as did catalase.”

“We show that adult neurogenesis within the dentate gyrus of the hippocampus is selectively impaired in a rat model of alcoholism, and that it can be completely prevented by the antioxidant ebselen.”

“We observed that ebselen exposure causes an increase in intracellular ROS levels and mitochondrial membrane potential, and that these effects were reversed by addition of antioxidants such as reduced glutathione (GSH) or N‐acetyl‐l‐cysteine (NAC).”