Possible Interaction: Antioxidants and Dopamine

“This toxic cascade was driven by oxidized dopamine, as mitochondriatargeted antioxidant treatment moderated the accumulation of dopamine and improved lysosomal glucocerebrosidase activity and proteolysis.”

“ Antioxidants blocked the effects of dopamine , but not MPP+, suggesting that oxidative stress was more important in the dopamine‐mediated effects.”

“It was also demonstrated that the antioxidants , N-acetylcysteine, and Sulforaphane, attenuated the toxicity of the mixture of As(+3) and DA to the SH-SY5Y cells.”

“Inhibiting DA uptake through dopamine transporter or treating the cell with antioxidants significantly reduced oxidative stress and dopamine toxicity.”

“DA 1 × 310−6 M was inhibited by the D1‐like receptor … effect of DA 5 × 3 10−4 M was prevented by the antioxidants … DA 0.1–10 × 3 10−6 M and 1–5×310−4 …; however, DA 5 × 3 10−4 M decreased caspase‐3 activity.”

“All these antioxidants inhibited the apoptosis induced by hydrogen peroxide, tumor necrosis factor alpha, dopamine and beta-amyloid peptide 1-42, since they were able to inhibit completely the mitochondrial membrane potential depolarization and the DNA fragmentation.”

“The influence of DA on chemokine production was not receptor mediated and could be prevented by antioxidants or radical scavengers.”

“These results suggest that DA toxicity is tightly linked to intracellular oxidant/antioxidant levels , and that environmental factors, such as excessive Mn exposure, may modulate cellular sensitivity to DA.”

“These results indicate that in aging and PD oxidative stress induces degeneration of dopamine neurons, and the antioxidant therapy may delay the decline of dopamine neurons in the brain.”

“Ascorbic acid (AA), included as antioxidant , totally restored cell loss in cultures treated with dopamine.”