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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Antioxidants
drug:
Dimethyl Fumarate
Research Papers that Mention the Interaction
“ DMF causes short-term oxidative stress and activates the antioxidant response via the transcription factor Nrf2 but its immunosuppressive effect is not well understood.”
Dimethyl fumarate alters intracellular Ca2+ handling in immune cells by redox-mediated pleiotropic effects.“ DMF induced a stronger antioxidant response as evidenced by a higher expression of Mn-superoxide dismutase.”
“Treatment of animals and dopaminergic SH-SY5Y cells with DMF resulted in increased nuclear levels of active Nrf2, with subsequent upregulation of antioxidant target genes.”
“In-vivo DMF treatment led to decreased T cell glycolysis and higher turn-over of antioxidants.”
“Results DMF treatment notably reduced histological damage as showed by cresyl violet staining; also, regulating both NF-κB and Nrf-2 pathway, DMF treatment decreased the severity of inflammation and increased the protective antioxidant action.”
Dimethyl fumarate alleviates the nitroglycerin (NTG)-induced migraine in mice“ DMF improves nerve regeneration via antioxidant and cytoprotective cell signaling pathways.”
“ConclusionsOur data suggest that DMF administration activates the Nrf2/Keap1 pathway, elevate levels of antioxidants , and decrease DNA damage and oxidative stress, resulting in improved ovarian reserve in the mouse ovary.”
“We found that DMF induced Nrf2 translocation to the nucleus, augmented Nrf2 promoter‐luciferase reporter activity and increased antioxidant enzyme expression.”
“The DMF 60 mg/kg treatment improved the level of antioxidants : glutathione peroxidase (GPx), superoxide dismutase (SOD), reduced glutathione (GSH) and reduced the lipid peroxidation as compared to corn oil + PTZ group.”
“ DMF treatment leads to an enhanced Nrf2 antioxidant response in TMEV-IDD mice.”
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