Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Antioxidants and Diethyldithiocarbamate

Research Papers that Mention the Interaction

3-Amino-1,2,4-triazole (3-AT, CAT inhibitor) and diethyldithiocarbamate (DETC, SOD inhibitor) which were used to inhibit CAT and SOD activity significantly blocked the antioxidant function of SIRT3.
Rejuvenation research  •  2020  |  View Paper
It is suggested that DDC might amplify cell damage by forming intracellular, loosely-bound complexes with copper and probably also by depleting antioxidant thiols.
Free radical research  •  1997  |  View Paper
Catalase as well as the antioxidants N-acetylcysteine (NAC) and glutathione (GSH) partially inhibited the cytotoxic effect of DDC + HOCbl, whereas ascorbate, pyruvate, and tiron, a scavenger of superoxide anion, had no cytoprotective effect.
Redox biology  •  2019  |  View Paper
On the other hand, … the higher dose of DDTC was given in association … either one of two antioxidants , alpha-tocopherol or melatonin, the amounts of SWS and PS significantly improved even on day 1, suggesting that the DDTC effects on sleep involved an impairment of the brain oxidative balance.
Brain Research  •  2002  |  View Paper
These results indicate that the protective effect of DDTC on chromium (VI)-induced cytotoxicity as well as lipid peroxidation may be associated with the level of nonenzymatic antioxidants such as vitamin E.
The Journal of veterinary medical science  •  1998  |  View Paper
We impaired antioxidant defense in normal vascular tissue by inhibiting catalase activity with 3-amino-1,2,4-triazole (AT), superoxide dismutase with diethyldithiocarbamate (DETC), and by reducing glutathione content via inhibiting glutathione synthesis with L-buthionine-(S,R)-sulfoximine (BSO).
The American journal of physiology  •  1991  |  View Paper