Possible Interaction: Antioxidants and Diclofenac

“Conclusion The use of antioxidant nutritional supplements, and in particular of Chr, may reduce the efficacy of Dic in inducing apoptosis of colon cancer cells.”

“Neutrophil glutathione peroxidase and total antioxidant status were lower in the patients than in the controls and higher post-treatment with diclofenac.”

“Thus, a mutual antioxidant effect between diclofenac acid and these antioxidants prolongs the lifespan of VC, VC‐12, VE and Trolox, respectively.”

“Treatment of hepatocytes with antioxidants (alpha-tocopherol, N,N-dimethylthiourea, superoxide dismutase) were able to prevent caspase cascade activation by diclofenac , revealing that oxidative stress at the mitochondrial level is involved in MPT induction.”

“Additionally, DCF induced significant changes in the expression of antioxidant genes including Mn-sod, cat, gst, and gpx.”

“To conclude, treatment with DCF could cause intestinal histological damage, induce significant changes of the expression of intestinal antioxidant genes , and impact the composition of intestinal microbiota in P. clarkii.”

“In general, diclofenac caused not only significant anti-oxidant adaptive responses for most levels of exposure, but also peroxidative damage.”

“Additionally, DCF elicited marked diminution in antioxidant enzyme and acetylcholinesterase (AChE) activities along with increase in nitric oxide (NO), reactive oxygen and nitrogen species (RONS), and lipid peroxidation (LPO) levels in the head, midgut and hemolymph of the insects.”

“In renal tissue, diclofenac also induced morphological changes consistent with kidney damage, modulated cytokine production, increased oxidative stress and reduced antioxidant defenses.”

“In conclusion, the results of these studies … us that the added presence of natural antioxidants could be beneficial as standard … therapeutics for a patient under diclofenac treatment, albeit that these effects do not appear to significantly build upon … could be obtained from this common anti-inflammatory agent per se.”

“In the present study, we investigated the potential beneficial impact of the addition of antioxidant supplements to diclofenac regimen in a model of carrageenan-induced paw.”

“In conclusion, diclofenac had beneficial effects decreasing Ox-LDL and improving antioxidant defense.”