Possible Interaction: Antioxidants and Dexamethasone

“Moreover, the pharmacological treatment of dyslipemia in patients undergoing type 2 DM (e.g. by means of statins), is accompanied by relevant side effects and oral supplementation with natural antioxidants , such as Citrus polyphenols, has recently been suggested to improve cardioprotection in such patients.”

“In the present study, we have demonstrated that dexamethasone treatment of A‐T lymphoblastoid cells increases the content of two of the most abundant antioxidants [glutathione (GSH) and NADPH] by up to 30%.”

“Furthermore, we observed that the inhibition of apoptosis by antioxidants correlated with an increased cell proliferation, suggesting that the immunomodulation of both DXM and CsA may be related to induction of apoptosis.”

“Totally, DEX suppressed growth performance and induced breast muscle oxidative injury in broilers, and FSE supplementation improved antioxidant capacity to attenuate these adverse effects.”

“Results: DM markedly induced systemic, hepatic, and renal inflammation and lowered antioxidant defense mechanisms.”

“ Dex administration … antioxidant enzyme activities (SOD, CAT, GSH‐PX), plasma melatonin level and melatonin receptor (MT1) expression with a concomitant increase in lipid peroxidation (TBARS) and altered testicular histopathology which might culminate into increased germ cell apoptosis as evident from increased Bax/Bcl‐2 ratio and caspase‐3 expression.”

“The antioxidant NAC can mitigate the oxidative stress damaging effects of DEX.”

“Data suggest that coadministration of antioxidant vitamins with Dex may be a helpful therapeutic strategy to reduce brain adverse effects of dexamethasone.”

“CONCLUSION DX co uld mitigate oxidative insult by up-regulation of Nrf2 and ant ioxidant en zymes, which may be an important mechanism involved in its protective effects on EAE.”

“Combined neonatal treatment of dexamethasone with antioxidant vitamins prevented these adverse side‐effects in offspring. •”