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Last Updated: 3 years ago

Possible Interaction: Antioxidants and Deoxycholate

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supplement:

Antioxidants

drug:

Deoxycholate

Research Papers that Mention the Interaction

“Either way, antioxidant supplementation may possibly help prevent the deleterious effects of DCA in the whole GI tract.”

The bile acid deoxycholic acid has a non-linear dose response for DNA damage and possibly NF-kappaB activation in oesophageal cells, with a mechanism of action involving ROS.

Mutagenesis • 2008 | View Paper

“The genotoxicity of DCA is however, ROS dependent, hence anti-oxidant supplementation, in addition to acid suppression may block DCA driven carcinogenesis in Barrett's patients.”

Deoxycholic acid at neutral and acid pH, is genotoxic to oesophageal cells through the induction of ROS: The potential role of anti-oxidants in Barrett's oesophagus.

Carcinogenesis • 2007 | View Paper

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