Possible Interaction: Antioxidants and Dehydroepiandrosterone

“Furthermore, enhanced clonogenic cell killing seen with the combination of DHEA+Au was nearly completely inhibited using the thiol antioxidant , N-acetylcysteine (NAC, 20 mM).”

“The findings showed that DHEA increased the antioxidant enzyme activity, decreased ROS generation, and inhibited apoptosis in H2O2-treated cells.”

“The results showed that DHEA increased the activity of total antioxidant capacity and superoxide dismutase, while it decreased the level of reactive oxygen species in LPS-induced mice.”

“In conclusion, … that DHEA reduces … regulating antioxidant enzyme activity; inhibits pro-inflammatory cytokines production by blocking the activation of p38 MAPK and NF-κB signal pathway; protects colon … via increasing tight junction protein expression and modulating gut microbiota taxa; all that finally alleviates DSS-induced experimental colitis in mice.”

“Moreover, DHEA stimulated the activation of Nrf2, which led to the expression of an antioxidant response gene , HO-1.”

“These results suggest that both antioxidants and anti-inflammatory properties mediate DHEA ’s effects for protection against muscle atrophy.”

“These effects were significantly inhibited by the antioxidant N-acetylcysteine (5mM) and the pentose phosphate pathway (PPP) inhibitor dehydroepianderosterone (200 microM).”

“The hypothesis that DHEA administration leads to an increase in antioxidant potency requires further investigations.”

“RESULTS There was a significant decrease (p < 0.05) in the an ioxidant an d metabolic enzyme activity in the DHE A tr eated group compared with the control group.”