Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 4 months ago

Possible Interaction: Antioxidants and Deferoxamine



Research Papers that Mention the Interaction

BACKGROUND Vitamin C, as antioxidant , increases the efficacy of deferoxamine (DFO).
BACKGROUND Vitamin C, as antioxidant , increases the efficacy of deferoxamine (DFO).
European journal of haematology  •  2016  |  View Paper
Moreover, DFX preconditioning significantly increased the total antioxidant capacity of the MSC secretome and they showed neuroprotective effects when evaluated in an in vitro model of DN.
PloS one  •  2017  |  View Paper
However, the cotreatments with various antioxidants , hydroxyl radical scavengers or intracellular Ca2+ release blockers significantly protected against the effects of DFO.
Toxicology letters  •  1995  |  View Paper
DFO significantly improved vital parameters of adipose tissue biology by reducing reactive oxygen species … (TNFα, IL-2, IL-6, and Hepcidin) secretion, by increasing the levels of antioxidant enzymes, hypoxia-inducible factor-1α (HIF-1α) and HIF-1α-targeted … by altering adipocytic iron-, glucose- and lipid-associated metabolism proteins.
Endocrine connections  •  2018  |  View Paper
DFO suppressed the Fas-induced production of reactive oxygen species (ROS) and the activation of caspase-3, both of which were also suppressed by antioxidant , N-acetyl-L-cystein.
Hepatology research : the official journal of the Japan Society of Hepatology  •  2011  |  View Paper
Even so, a combined treatment with NAC and DFX produced a stronger increase of antioxidant activities in the prefrontal cortex, amygdala and hippocampus.
Neurochemistry International  •  2012  |  View Paper
The results obtained revealed that DFO enhances antioxidant activity in the host but also increases oxidative stress, indicating that the mode of action of the drug involves a positive contribution to the host together with an effect that is not beneficial to the parasite.
Redox report : communications in free radical research  •  2010  |  View Paper
Lipid peroxidation was attenuated by both antioxidant treatments, but the effects of NAC plus DFX were of greater magnitude.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association  •  2009  |  View Paper
In the prefrontal cortex, the protein carbonyls were not affected by the treatment with antioxidants alone but it was increased by treatment with NAC plus DFX.
Progress in Neuro-Psychopharmacology and Biological Psychiatry  •  2008  |  View Paper
This indicates that DFO possibly exerts its protective role by directly influencing the antioxidant capacity of HO-1.
Journal of neurochemistry  •  2001  |  View Paper
Show More