Possible Interaction: Antioxidants and Deferoxamine

“Vitamin C, as antioxidant , increases the efficacy of deferoxamine (DFO).”

“However, DFO administration effectively prevented the Pb-induced alterations of these antioxidant enzymes activities.”

“Moreover, DFX preconditioning significantly increased the total antioxidant capacity of the MSC secretome and they showed neuroprotective effects when evaluated in an in vitro model of DN.”

“However, the cotreatments with various antioxidants , hydroxyl radical scavengers or intracellular Ca2+ release blockers significantly protected against the effects of DFO.”

“ DFO also significantly counteracted the CCl4‐induced lipid peroxidation increase and reduction in antioxidant activities of superoxide dismutase and glutathione peroxidase enzymes.”

“Furthermore, DFO prevented the K(2)Cr(2)O(7)-induced renal oxidant stress and the decrease in the activity of the antioxidant enzymes superoxide dismutase, glutathione reductase, glutathione peroxidase, glutathione-S-transferase and catalase.”

“Even so, a combined treatment with NAC and DFX produced a stronger increase of antioxidant activities in the prefrontal cortex, amygdala and hippocampus.”

“Lipid peroxidation was attenuated by both antioxidant treatments, but the effects of NAC plus DFX were of greater magnitude.”

“In the prefrontal cortex, the protein carbonyls were not affected by the treatment with antioxidants alone but it was increased by treatment with NAC plus DFX.”

“This indicates that DFO possibly exerts its protective role by directly influencing the antioxidant capacity of HO‐1.”