Possible Interaction: Antioxidants and Curcumin

“In conclusion, our data identify that curcumin could enhance Nrf2-mediated HO-1 to upregulate antioxidant ability , which might be associate with CYP450 signaling to suppress liver damage induced by HgCl2.”

“ Curcumin or THC complexes in HP-CDs with improved bioavailability also induced anti-oxidant activity (SOD1, CAT1, and HMOX1) in higher levels in the ocular epithelial cells and showed oxidative protection effects in rabbit cornea tissues that will boost up their application in ocular medicine.”

“We summarize the in vivo and … mechanisms of action in which curcumin modifies AD pathology: curcumin inhibits the formation and promotes the disaggregation of amyloid-β plaques, attenuates the hyperphosphorylation … clearance, binds copper, lowers cholesterol, modifies microglial activity, inhibits acetylcholinesterase, mediates the insulin signaling pathway, and is an antioxidant.”

“ Curcumin significantly enhanced the antioxidant defense , while DNC induced apoptosis and reduced viability as well as survival of irradiated THP-1 cells.”

“The photoprotective effect provided by curcumin was potential associated with modulation of Nrf2‐dependent antioxidant response.”

“Pretreatment of cells with RSVL, curcumin , and EEAC increased the cell antioxidant ability by improving the activity of superoxide dismutase (SOD), prevented or limited intracellular damage, and ameliorated the harmful effects of ROS.”

“In this regard, some phytochemicals, such as sulforaphane, brazilin, chalcone, resveratrol, and curcumin , are reported to modulate translocation and activation of the nuclear factor-erythroid-2-related factor (Nrf2) and regulate antioxidant response [3].”

“Moreover, curcumin significantly reduced LRRK2 kinase activity and the levels of oxidized proteins, and thus acted as not only an antioxidant but also a LRRK2 kinase inhibitor.”

“The suppression of mitogen-induced T cell proliferation and cytokine secretion by curcumin and DiMC was significantly abrogated by thiol containing antioxidants suggesting a role for redox in their anti-inflammatory activity.”

“Similarly, natural antioxidants curcumin and ginkgo extract have modest but positive effects in slowing AD development.”