supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 4 years ago
supplement:
Antioxidants
supplement:
Cupric Cation
Research Papers that Mention the Interaction
“The effects of Cu2+ were inhibited by a number of lipophilic antioxidants , including probucol, vitamin E, butylated hydroxytoluene, and a 21-aminosteroid, U74389G.”
Copper-induced tissue factor expression in human monocytic THP-1 cells and its inhibition by antioxidants.“Addition into the … medium of the antioxidant N-acetylcysteine (NAC, 1 mM) in the presence of Cu2+ (0.0005-0.001 mM) induced intensive death of cultured rat cerebellar granule neurons, which was significantly decreased by the zinc ion chelator TPEN (N,N,N′,N′-tetrakis(2-pyridylmethyl)ethylenediamine).”
N-acetyl-L-cysteine in the presence of Cu2+ induces oxidative stress and death of granule neurons in dissociated cultures of rat cerebellum“In addition, cupric stress induced changes in antioxidant enzyme activities.”
Cupric stress induces oxidative damage marked by accumulation of H2O2 and changes to chloroplast ultrastructure in primary leaves of beans ( Phaseolus vulgaris L.).“Antioxidant tests in vitro show the compounds possess significant antioxidant activity against superoxide and hydroxyl radicals, and the scavenging effects of Cu(II) complex are stronger than Zn(II), Ni(II) complexes and some standard antioxidants , such as mannitol and vitamin C.”
“In the presence of Cu(II) ions , the antioxidant KA (3.1-200 microM) but not KP (6-384 microM) caused a concentration-dependent pBR322 plasmid DNA strand scission.”
“ Antioxidants (butylated hydroxytoluene, sodium ascorbate, purified β-carotene, α-tocopherol) inhibit, while bivalent ions ( cupric , cobaltous) stimulate, consistent with the occurrence of a cyclic peroxidation.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback