Possible Interaction: Antioxidants and Corticosterone

“CONCLUSION The results showed that the extract and isolated co pounds ex hibited significant ant ioxidant activities. ”

“This provides novel evidence that dietary antioxidants attenuate the activation of the HPA axis (i.e. increased secretion of corticosterone ) during long-duration flight.”

“ Corticosterone and TNF-α were significantly (p < 0.01) reduced and biogenic amines were increased with antioxidant markers, which signify the potential influence of DAEA on neuroprotection.”

“ Corticosterone pre-treatment generated oxidative stress, altering antioxidant enzymes in the nervous tissue.”

“The data presented … substantial decline in antioxidant defences … corticosterone , evidenced by coordinate decreases in the activities in the brain, liver and heart of free-radical scavenging enzymes superoxide dismutase (…), glutathione S-transferase (GST) and glutathione reductase (GR), as well as the non-enzymatic antioxidants glutathione (GSH) and serum urate.”

“High levels of corticosterone may be associated with low individual fitness and may affect balance between pro-oxidants and antioxidants.”

“Both positive and negative correlations between antioxidant response and corticosterone response were occasionally but not consistently present, refuting a generalized regulation‐by‐corticosterone hypothesis.”