Possible Interaction: Antioxidants and Copper

“ Antioxidant supplementation … Cu at 30 degrees C and 37 degrees C. At 30 degrees C the lag phase increased from 55 to 129 minutes (p<0.… 78 to 33 nmoles MDA/mg LDL protein (p<0.0001); and free amine loss decreased from 41 to 12% (p<0.0001).”

“Supplementation of diabetic subjects with antioxidant vitamins significantly decreases susceptibility of LDL to oxidation by Cu.”

“Promoter analysis and EMSA revealed that copper stimulates the Atox1 binding to a previously undescribed cis element in the cyclin D1 promoter.”

“Glycated BSA still behaved as an antioxidant but became pro‐oxidant in the presence of copper , probably by generating oxygenated species.”

“Wheat germ oil antioxidants were found effective in inhibiting deterioration due to copper.”

“CONCLUSIONS: The clinical and nutritional status as well as intake of nutrients with ntioxidant properties (C u, Zn, Mn, vitamin C and ω3) appears to modulate the variation of NO in this population.”

“Among the metal ions examined, only iron and copper generated ROS in the presence of antioxidants.”

“In this article, we show that dietary antioxidants can alternatively switch to a prooxidant action in the presence of transition metals such as copper.”

“It is known that antioxidants such as ascorbate also exhibit prooxidant activity in the presence of transition metals such as copper.”

“Although apparently in contrast with the common view that Cu(I) and not Cu(II) is the real trigger species of LDL … model, the results reported here indicate that the availability of Cu(I) during the initiation phase of LDL oxidation promoted by copper … antioxidant consumption and … extensive oxidation.”

“The present data demonstrate that copper and iron ions modify the cytotoxic activity of these antioxidants differently and their radical intensity is not the sole determinant of cytotoxic activity.”