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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Antioxidants
drug:
Clofazimine
Research Papers that Mention the Interaction
“Arachidonate per se at a concentration of 20 microM did not affect mitogen-activated lymphocyte proliferation, while cyclooxygenase and 5'-lipoxygenase inhibitors, as well as water- and lipid-soluble oxidant-scavengers and anti-oxidant enzymes , failed to protect the cells against the anti-proliferative effects of clofazimine and B669.”
Clofazimine and B669 inhibit the proliferative responses and Na+, K(+)-adenosine triphosphatase activity of human lymphocytes by a lysophospholipid-dependent mechanism.“ Clofazimine mediated inhibition of PMNL migration was prevented by the anti-oxidants cysteine and dapsone but not by the potent inhibitors of PG synthetase indomethacin and piroxicam.”
“Supporting the ROS-based killing mechanism, bacteria grown in the presence of antioxidants are more resistant to CFZ.”
Reduction of Clofazimine by Mycobacterial Type 2 NADH:Quinone Oxidoreductase
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