Possible Interaction: Antioxidants and Citrulline

“In addition, research that has investigated the potential synergistic effects of L-citrulline with other dietary ingredients (e.g., arginine, antioxidants , nitrates, and branched-chain amino acids) is reviewed.”

“Taken together, these results may indicate that L-citrulline and ammonia decreased the antioxidant capacity of the brain, which may reflect a possible involvement of oxidative stress in the neuropathology of citrullinemia.”

“Both antioxidants , however, significantly prevented the increase of citrulline and the depletion of high-energy phosphates.”

“Together, these data indicates that L-Cit influenced the antioxidant defense , heat shock response and nitric oxide regeneration both under thermoneutral and HS conditions; and that L-Cit may be directly and/or indirectly involved in the central regulation of body temperature.”

“ Anti-oxidant enzymes including catalase and superoxide dismutase (SOD) were increased with L-Cit supplementation, however, SOD activity was unchanged at 4 th week, while total anti-oxidant capacity increased at the 8 th week.”