Possible Interaction: Antioxidants and Cisplatin

“Plasma concentrations of antioxidants decrease significantly during cisplatin chemotherapy for cancer.”

“The evidence is growing over the protective effects of antioxidants on cisplatin‐induced adverse reactions especially nephrotoxicity.”

“A combination of cisplatin with antioxidants resulted in successful reduction of nephrotoxicity by normalizing the enzymatic levels of various liver and kidney function tests.”

“However, high doses of cisplatin produce impairment of kidney, which can be reduced by the administration of antioxidants.”

“Reduction in parasite load, increase in Th1 type of immune responses, and normalization of various biochemical parameters occurred in animals treated with cisplatin in combination with various antioxidants as compared to those treated with the drug only.”

“The above results are promising as antioxidants reduced the potential toxicity of high doses of cisplatin , making the combination a potential anti-leishmanial therapy, especially in resistant cases.”

“A combination of cisplatin and antioxidants might provide more advantage than cisplatin alone in the treatment of cancer patients with chronic HBV infection.”

“Importantly, antioxidants blocked activation of caspase-3 and acceleration of Mcl-1 loss, as well as cell death, in HBx-expressing hepatocytes upon cisplatin exposure in vitro and in vivo.”

“Furthermore, in in vitro experiments, antioxidants or reactive oxygen species (ROS) scavengers have a cytoprotective effect on cells exposed to cisplatin.”

“It is believed that cisplatin suppresses the formation of endogenous anti-oxidants that normally prevent the inner ear against reactive oxygen species (ROS).”

“Cisplatin (CDDP), an anticancer drug, induces remarkable toxicity in the kidneys of animals and humans and it has been well documented that reactive oxygen species and the renal antioxidant system are strongly involved in acute renal damage induced by CDDP.”

“ Antioxidants such as sodium thiosulfate (STS) can neutralize the effects of cisplatin.”

“Co-treatment with SS and ROS-generating drugs dramatically elevated ROS levels in CTCs, while the addition of antioxidants abolished the pro-apoptotic effects of DOX and cisplatin.”

“In joint exposure with cisplatin all three antioxidants , in the most of concentrations, decreased TBARS levels, elevated by cisplatin (p < 0.05).”