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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Antioxidants
drug:
Chenodeoxycholate
Research Papers that Mention the Interaction
“Our results demonstrate that CDCA induces antioxidant and xenobiotic-metabolizing enzymes by activating C/EBPβ through AMPK-dependent ERK1/2 pathway downstream of FXR.”
Farnesoid X Receptor Activation by Chenodeoxycholic Acid Induces Detoxifying Enzymes through AMP-Activated Protein Kinase and Extracellular Signal-Regulated Kinase 1/2-Mediated Phosphorylation of CCAAT/Enhancer Binding Protein β“Further, the involvement of oxidative stress in cerebrotendinous xanthomatosis indicates that combined therapy with chenodeoxycholic acid and antioxidants may improve clinical outcome.”
“Thus, we evaluated (a) the effects of bile acids (0–200 μmol L−… lymphocyte reduced glutathione content and malondialdehyde production and (b) the ability of antioxidants to prevent the … effect of chenodeoxycholic acid on interferon‐induced lymphocyte 2′,5′‐oligoadenylate synthetase …, an index of the biological activity of interferon.”
“Metabolomic analysis showed that the metabolic processes responsible for antioxidant … disrupted by NET (e.g. upregulation of nervonyl carnitine and chenodeoxycholic acid 3-sulfate; downregulation of homolanthionine …) and these changes can undermine antioxidant defence by suppressing Nrf2-ARE and NF-κB pathways … to the synthesis of SOD and GSH.”
Norethindrone causes cellular and hepatic injury in zebrafish by compromising the metabolic processes associated with antioxidant defence: Insights from metabolomics.
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