Possible Interaction: Antioxidants and Carotenoids

“These results suggest that the carotenoids are capable of exerting two overlapping but distinct effects: antioxidant protection by scavenging DNA-damaging free radicals and modulation of DNA repair mechanisms.”

“The results suggest that both moderate antioxidant supplementation and a diet high in carotenoids elevate serum carotenoids and antioxidant levels in an older adult population, although with different specific effects.”

“Many phytochemicals possess antioxidant and anti-inflammatory properties that may positively affect the GM, including polyphenols, carotenoids , phytosterols/phytostanols, lignans, alkaloids, glucosinolates and terpenes.”

“Several studies have indicated that carotenoids used in combination were more effective on antioxidation and anticancer actions than carotenoids used singly.”

“Obviously, on certain conditions of high-dose carotenoid supplementation, both the antioxidant and prooxidant reactions may arise.”

“They interact synergistically with other antioxidants ; mixtures of carotenoids are more effective than single compounds.”

“The effectiveness of carotenoids as antioxidants is also dependent upon their interaction with other coantioxidants , especially vitamins E and C. Carotenoids may, however, lose their effectiveness as antioxidants at high concentrations or at high partial pressures of oxygen.”

“It is quite clear that in vitro, carotenoids can inhibit the propagation of radical‐initiated lipid peroxidation, and thus fulfill the definition of antioxidants.”

“It is suggested that the antioxidant function of carotenoids may explain their divergent effects as chemopreventive agents.”

“ Carotenoids may strengthen the association of antioxidant vitamins A, C, and E with favorable cognitive outcomes over time, though a few prospective studies have examined this hypothesis.”