Possible Interaction: Antioxidants and Cardiotonic Agents

“In addition, research demonstrating adverse effects of oxidants on atherogenesis raises the possibility that antioxidants can confer cardioprotective effects.”

“An antioxidant completely abolished cardioprotection and the activation of Mn-SOD by exercise or the injection of TNF-α as well as exercise-induced increase in TNF-α and IL-1β.”

“These results suggest that H2O2 may act as a signal-transducing molecule, and they suggest a potential mechanism for the cardioprotective effects of antioxidants.”

“ Cardioprotective interventions with antioxidants or chelators have nevertheless produced conflicting results.”

“Thus, antioxidant pretreatment significantly improves mitophagic response to ISO in old myocardium, which may contribute to restoration of cardioprotection in senescent animals.”

“The majority of mRNAs of antioxidant genes related to mitochondrial antioxidant defense (manganese superoxide dismutase, glutathione reductase, thioredoxin/thioredoxin reductase, and peroxiredoxin 2) were upregulated in both cardioprotective regimens (CNH, INH8).”

“and superoxide (O2 .-), and that cardioprotection is abrogated by antioxidants.”

“Taken together, our data … that intervention with an antioxidant treatment for 4-… leads to significant cardioprotection against diabetes-induced injury, controlling oxidant/antioxidant level, which may directly control the levels of some miRNAs … miR-1 and its target protein junctin, which is involved in the development of diabetic cardiomyopathy.”

“The cardioprotection was associated with a differential enhancement in mitochondrial antioxidant components.”

“Because exercise and antioxidants may provide cardioprotection via different mechanisms, combining these countermeasures could provide additive protection.”