Possible Interaction: Antioxidants and Carbamazepine

“After a 30-… therapy with carbamazepine (… antioxidant Mexicor , inhibition of generator activity of limbic and hypothalamic as well as stem and cerebellum structures and displacement of generator zones into … were observed that may be explained by enhancement of determinant foci of the cortical structures in inhibition of secondary foci.”

“Both classical analgesics (nonsteroidal …, escitalopram, phenytoin or carbamazepine … antioxidant processes in the mammalian tissues and these properties of drugs such as indomethacin, meloxicam, tenoxicam, valdecoxib or some metabolites of analgesic … and drug-related toxic effects, including gastrointestinal ulcers, hepatic failure, agranulocytosis, aplastic anemia, neutropenia, opiate-induced hyperalgesia and tolerance.”

“The results demonstrated that, in comparison with single exposure group, the combined presence of CBZ and Cu exacerbated the effect of antioxidant system (the ability of inhibition of hydroxyl radicals (IHR), superoxide dismutase (SOD), catalase (CAT) and glutathione S‐transferase (GST)) but not nervous system (Acetylcholinesterase [AChE]).”

“Overall, the present study demonstrated that the higher CBZ concentrations can lead to the impairment of antioxidant enzymes compromising the neutralization of reactive oxygen species, and thus the ability to cope with oxidative stress.”

“After 2h exposure of CBZ at higher test concentration (2.0 or 20 mgL(-1)), oxidative stress was apparent as reflected by the significant higher LPO and CP levels in fish spermatozoa, as well as the significant inhibition of antioxidant enzymes activities including SOD, GR and GPx.”

“Prolonged exposure to CBZ resulted in excess reactive oxygen species formation, finally resulting in oxidative damage to lipids and proteins and inhibited antioxidant capacities in fish brain.”

“Therefore combining CBZ with antioxidants could be beneficial.”