Possible Interaction: Antioxidants and Captopril

“ CP administration increased renal expression of antioxidant and anti-inflammatory markers, which was reduced by OA.”

“ CP induced marked deteriorations in serum liver function biomarkers, reduced antioxidant enzymes in tissue, while elevated tissue oxidative stress markers along with morphological injuries compared to control rats.”

“Use of sulfhydryl ACE-inhibitors (ACEIs), such as zofenopril or captopril , plus xanthine oxidase inhibitors (XOIs), may potentially result in enhanced antioxidant effects and improved survival.”

“The increased local levels of oxidants can induce inflammatory mediators and pathways that cause pain, directly or indirectly.4 Therefore, longerm administration of antioxidants should reduce pain n patients with CP.”

“Antioxidant effect of captopril is believed to be due to increase in enzymes of bodily antioxidant defense , such as glutathioneperoxidaze, glutathionereductaze, and elevation in blood levels of vitamin E and reduced glutathione.”

“Conclusion: Our findings showed that the combined use of high-dose aspirin, metformin, captopril and atorvastatin potentiated their antioxidant effects on the brain, and hence could potentially improve cognitive function with their neuroprotective effects on hippocampus.”

“ CP also significantly increased the plasma concentration of inflammatory cytokines [plasma tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and interleukin-1beta (IL-1β)] and significantly reduced antioxidant indices [catalase, glutathione reductase (GR), and superoxide dismutase (SOD)].”

“In addition, CP caused a marked decline in the activities of enzymatic antioxidants and mitochondrial complexes (I, II, III and V) in liver mitochondria.”

“Our results suggest that captopril protects against cysteamine-induced duodenal ulcer and inhibits the decrease in SOD and GSH-PX activities and lipid peroxidation by increasing antioxidant defenses.”

“Acute intoxication of rats with CP was followed by statistically significant decreased activity of antioxidant defense enzymes: superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR) and glutathione-S-transferase (GST).”