Possible Interaction: Antioxidants and Caffeic Acid

“3,4,5-Trihydroxycinnamic acid THCA ), a derivative of hydroxycinnamic acid, has been reported to exert anti-inflammatory and antioxidant activities.”

“Treatment with CA and Res increased the levels of antioxidant and autophagy protein expression with consequently corrected levels of reactive oxygen species, mitochondrial membrane potential, mutant ataxin‐3, and the aggregation of mutant ataxin‐3 in SK‐N‐SH‐MJD78 cells.”

“Our data show that CA inhibits HG-induced nuclear translocation of NF-κB and the downstream expression of endothelial adhesion molecule 1 and restores antioxidant levels by upregulating Nrf2/EpRE pathway.”

“Further, caffeic acid pretreatment significantly maintains antioxidant status and decreased UVB-induced cytotoxicity.”

“The phenolic antioxidant caffeic acid inhibits lipoprotein oxidation induced by peroxyl radicals, either in native or photosensitizer-loaded fractions, delays hemolysis of erythrocytes and partially prevents membrane loss of SH groups in ghosts, but not the efflux of K + .”

“It can be concluded that caffeic acid exerts an antioxidant action inside the cell, responsible for the observed modulation of the cellular response to oxidative challenge.”

“ Caffeic acid significantly up‐regulated the immune and antioxidant related genes of fish.”

“Our results show that CA significantly inhibit the TPA induced lipid peroxidation (LPO), inflammatory responses, tumor necrosis factor alpha (TNF-α) release and also found to up regulate GSH content and the activity of different antioxidant enzymes.”

“In addition, CA significantly reduced lipid peroxidation and restored the levels of antioxidant defense in the liver.”

“In the carcinogenicity study, slightly increased incidences of … were found in the sesamol- (15.8%), caffeic acid- (14.8%), catechol- (3%) and 4-MP- (11.5%) treated groups as … with basal diet (0%), and a significant increase was observed with the five antioxidants in combination (42.…%, P < 0.001).”