Possible Interaction: Antioxidants and Butylated Hydroxytoluene

“We have identified 14 very sensitive parameters, which may play a major role on the antioxidant performance of BHT.”

“The addition of antioxidants (N-acetyl-Lcysteine, sodium ascorbate, catalase) reduced the cytotoxicity of BHA/BHT or BMP against HSC-2 cells, but not that of BHA or BHT, whereas the addition of NADH, a quinone reductase to BMP, enhanced the cytotoxicity.”

“Their formation and action can be inhibited by antioxidants such as those in soy, tea, vitamin C and also by the synthetic antioxidants BHA or BHT.”

“… antioxidants prevent carcinogenesis,12 possibly by decreasing the attachment of the …).S The potent food additive antioxidants, butylated hydroxyanisole and butylated hydroxytoluene , recently have been shown to decrease the incidence of stomach cancer in mice;… relationship has been observed between the potent antioxidant, selenium, and human cancer mortality.8”

“These findings proved that BHT inhibits Hg2+-toxicity, hindering ROS generation and intrinsic apoptosis, via enhancing glutathione and antioxidants ; and suggested BHT implications as therapeutic.”

“Consuming 2.32–23.80 mg/kg·bw/d (150–1500 mg/kg in diet) of BHT effectively improved the plasma and hepatic lipid metabolism, antioxidant response as well as reduced ROS production, protecting hepatic cells from injury.”

“The antioxidant response , especially plasma glutathione peroxidase was enhanced by BHT inclusion.”

“In mammals, dietary antioxidants , such as butylated hydroxytoluene (BHT), have been shown to lessen the toxic effects of AFB(1) by various mechanisms.”

“These results indicate that BHT counteracts many of the deleterious effects caused by AFB(1) and that this antioxidant may prove to be a viable feed additive for the reduction of aflatoxicosis in turkeys.”

“Concerning creatine kinase (… preventive effect of antioxidants (…: BHT (30), trolox (75), stobadine (ST) (77), alpha-phenyl-N-tert-buthylnitrone (PBN) (87), sodium salt of N-tert-buthyl-C-(phenyl-… loss of CK activity in percentages, when 100% was the loss of CK activity in the absence of any antioxidant).”

“Therefore, we show that alterations of the antioxidant status in NOD mice is efficaciously counteracted by BHT.”

“A significant decrease in these parameters was found with the simultaneous antioxidant treatment, HTHQ demonstrating the greatest effect, followed by BHA, BHT and TBHQ, and PG.”