Possible Interaction: Antioxidants and Bleomycin

“Also antioxidant enzymes level have occurred as, at least partly, participating in bleomycin cytotoxic efficiency.”

“We show that levels of antioxidants (SOD, GSH cycle, and GST) affect cellular cytotoxic responses to bleomycin , at normal and elevated temperatures (41 to 44 degrees C), suggesting the involvement of oxidative stress.”

“Our results highlight the important role of membrane fatty acid remodeling occurring during the use of bleomycin and its concurrent use with antioxidants which can adjuvate the cytotoxic effects of the chemotherapeutic agents.”

“Oxidative stress parameters, such as glutathione (GSH), malondialdehyde (MDA), and antioxidant enzyme activities were altered upon BLM treatment.”

“ Bleomycin and H2O2 significantly decreased the antioxidant capacity and GSH levels in NTera-2 cells.”

“ Bleomycin and H(2)O(2) significantly decreased antioxidant capacity and GSH levels in both cell lines.”

“The endogenous antioxidant catalase abolished effects with H2O2, but only slightly affected the response with BLM.”

“ BLM instillation increased oxidant load with quenching of antioxidant defenses together with increase inflammatory and fibrotic cytokines expression.”

“Intratracheal administration of bleomycin (6.5 U/kg body weight) to rats resulted in significant reduction of body weight, enzymic antioxidants (superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase) and non-enzymic antioxidants (reduced glutathione, vitamin C, vitamin E and vitamin A).”

“These results show that BLM induces changes in the antioxidant system of T2 cells, particularly in the glutathione system.”