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Last Updated: 3 years ago

Possible Interaction: Antioxidants and Bleomycin

supplement:

Antioxidants

Research Papers that Mention the Interaction

Also antioxidant enzymes level have occurred as, at least partly, participating in bleomycin cytotoxic efficiency.
Acta poloniae pharmaceutica  •  2000  |  View Paper
We show that levels of antioxidants (SOD, GSH cycle, and GST) affect cellular cytotoxic responses to bleomycin , at normal and elevated temperatures (41 to 44 degrees C), suggesting the involvement of oxidative stress.
Archives of biochemistry and biophysics  •  1999  |  View Paper
Our results highlight the important role of membrane fatty acid remodeling occurring during the use of bleomycin and its concurrent use with antioxidants which can adjuvate the cytotoxic effects of the chemotherapeutic agents.
Biochimica et biophysica acta  •  2016  |  View Paper
Oxidative stress parameters, such as glutathione (GSH), malondialdehyde (MDA), and antioxidant enzyme activities were altered upon BLM treatment.
Free radical research  •  2013  |  View Paper
Bleomycin and H2O2 significantly decreased the antioxidant capacity and GSH levels in NTera-2 cells.
Molecular medicine reports  •  2012  |  View Paper
Bleomycin and H(2)O(2) significantly decreased antioxidant capacity and GSH levels in both cell lines.
Biochimie  •  2012  |  View Paper
The endogenous antioxidant catalase abolished effects with H2O2, but only slightly affected the response with BLM.
Mutation research  •  1994  |  View Paper
BLM instillation increased oxidant load with quenching of antioxidant defenses together with increase inflammatory and fibrotic cytokines expression.
Life sciences  •  2019  |  View Paper
Intratracheal administration of bleomycin (6.5 U/kg body weight) to rats resulted in significant reduction of body weight, enzymic antioxidants (superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase) and non-enzymic antioxidants (reduced glutathione, vitamin C, vitamin E and vitamin A).
Biological & pharmaceutical bulletin  •  2008  |  View Paper
These results show that BLM induces changes in the antioxidant system of T2 cells, particularly in the glutathione system.
Cell Biology and Toxicology  •  2004  |  View Paper
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