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“The magnitude of destruction of antioxidants , such as carotenoids, can serve as a marker of the extent of the stress factor , characterized by the quantity of produced free radicals.”
“Consistently, our data revealed as well that mitigation of intracellular ROS levels with antioxidant NAC markedly attenuated H2O2-induced AMPK activation and ER stress.”
International journal of medical sciences • 2018 | View Paper
“The observation that targeting oxidative stress with antioxidants has been associated with unfavorable clinical outcomes and the recognition that in cell cultures antioxidants may aggravate ER stress , suggests that selective targeting of individual cellular stresses may not be sufficient for preventing glucotoxicity.”
Journal of cellular and molecular medicine • 2009 | View Paper
“Ethanol rapidly caused oxidative stress in cultured neuronal cells; antioxidants blocked ethanol's potentiation of ER stress and cell death, suggesting that the ethanol‐promoted ER stress response is mediated by oxidative stress.”