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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Antioxidants
drug:
Atorvastatin
Research Papers that Mention the Interaction
“ ATO reduced Nrf2 and antioxidant enzyme superoxide dismutase‐2 (SOD2) expression in human hepatocarcinoma HepG2 cells.”
“For example, atorvastatin combined with antioxidants (vitamin E and vitamin C) effectively reduced hepatic steatosis.”
Nonalcoholic fatty liver disease: Is it time for combination treatment and a diabetes‐like approach?“RESULTS After 4-week treatment, at rvastatin an d rosuvastatin were associated with significant reduction in TAS , O SI, total cholesterol, and LDL-C levels.”
“ Atorvastatin treatment significantly reduced the levels of total cholesterol (24.5%), low density lipoprotein (LDL) cholesterol (25.4%), triglycerides (24.4%), CD (4.4%), MDA (15.2%), TP (13.0%) and OSI (24.0%), and significantly increased the levels of TAS (27.3%), and PON1 activity (14.0%).”
“It was observed a significant increase of the antioxidant enzyme activities during atorvastatin and simvastatin treatment.”
“The activities of antioxidants enzymes (CAT, GSH-Px, SOD) significantly increased after 4 weeks therapy in patients treated with atorvastatin and simvastatin.”
“Conclusion: Our findings showed that the combined use of high-dose aspirin, metformin, captopril and atorvastatin potentiated their antioxidant effects on the brain, and hence could potentially improve cognitive function with their neuroprotective effects on hippocampus.”
Comparison of the Neuroprotective Effects of Aspirin, Atorvastatin, Captopril and Metformin in Diabetes Mellitus“ Atorvastatin might protect the tissues via its antioxidant property and by modulating the antioxidant enzymes through the Nrf2 signalling pathway, which may be the underlying mechanisms of these protective effects.”
“ Atorvastatin and sildenafil exert antioxidant and pleiotropic effects that may result in cardiovascular protection.”
“Administration of ATO enhanced ALT, ALP level, increased reactive oxygen species (ROS) production and altered the pro oxidant-antioxidant status of liver by reducing intracellular GSH level, anti-oxidant enzymes activities and increasing intracellular lipid peroxidation.”
“INTRODUCTION Atorvastatin has antioxidant activity and has been reported to increase blood antioxidant capacity.”
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