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Discover Supplement-Drug Interactions

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Last Updated: 4 months ago

Possible Interaction: Antioxidants and Aspartame



Research Papers that Mention the Interaction

This study investigates how long-term (40 mg/kg b.wt) consumption of aspartame can alter the antioxidant status , stress pathway genes, and apoptotic changes in the liver of Wistar albino rats.
Journal of food and drug analysis  •  2015  |  View Paper
The existing animal … suggest that aspartame and its metabolites, whether consumed in quantities significantly higher … or within recommended safe levels, may disrupt the oxidant/antioxidant balance , induce oxidative stress, and damage cell membrane integrity, potentially affecting a variety … causing a deregulation of cellular function, ultimately leading to systemic inflammation.
Nutrition reviews  •  2017  |  View Paper
It is clear that long term aspartame exposure could alter the brain antioxidant status, and can induce apoptotic changes in brain.
Redox biology  •  2014  |  View Paper
The results of this experiment indicate that long-term consumption of aspartame leads to an imbalance in the antioxidant/pro-oxidant status in the brain, mainly through the mechanism involving the glutathione-dependent system.
Drug and chemical toxicology  •  2013  |  View Paper
It can be concluded from these observations that long term consumption of aspartame leads to hepatocellular injury and alterations in liver antioxidant status mainly through glutathione dependent system.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association  •  2011  |  View Paper