Possible Interaction: Antioxidants and Artesunate

“ Artesunate promoted anti-oxidant catalase activity and reduced NADPH oxidase 2 (NOX2) protein level in the lungs from cigarette smoke-exposed mice.”

“ Antioxidant stress genes (thioredoxin, catalase, gamma-glutamylcysteine synthetase, glutathione S-transferases) as well as the epidermal growth factor receptor confer resistance to artesunate.”

“ Anti-oxidant stress genes (thioredoxin, catalase, gamma-glutamyl-cysteine synthetase, glutathione S-transferases) as well as the epidermal growth factor receptor confer resistance to artesunate.”

“Taken together these data support a role for oxidative stress in the mechanism of ART action in tumor cells and suggest that antioxidant defenses act in combination to affect the cellular response to ART.”

“The antioxidant trolox-pretreatment significantly decreased the growth inhibition effect of ART on SKM-1 cells.”

“By using transfected or knockout cell models we found that the tumor suppressor p16(INK4A) and the anti-oxidant protein , catalase, conferred resistance towards ART , while the oncogene HPV-E6 conferred sensitivity towards ART.”

“Treatment with a potent antioxidant might conceivably protect parasites from the oxidative burst of phagocytes and could antagonize the oxidation-mediated antimalarial effects of artesunate.”

“Consistently, we also demonstrated that ARS effectively suppressed ROS production, leading to the inhibition of arthritic bone destruction by activating antioxidant enzyme and Nrf2/p62 signaling in the knee and ankle tissues of CIA rats.”

“Oral administration of ART and PRG altered antioxidant enzymes status, Caspases 3 and 9 were significantly activated in PRG-treated groups; there was significant increase in DNA fragmentation in PU and PRG groups compared with the normal control.”

“Similarly, LPO level was decreased and antioxidant activities were enhanced after ART treatment.”