Possible Interaction: Antioxidants and Arachidonic Acid

“It was found that antioxidant substances which act like OFR "scavengers" cause inhibition of arachidonic acid derivatives production and also inhibition of platelets activation.”

“ Antioxidants prevented the L-NAME potentiation of AA toxicity.”

“Treatment with antioxidants prior to stimulation with AA was also ineffective in preventing its antiproliferative effect.”

“ Antioxidants modulate also the formation of products derived from long-chain polyunsaturated fatty acids, such as arachidonic acid --which are structural components of biological membranes--through oxidative reactions involving the cyclooxygenase and lipoxygenase systems.”

“Moreover, AA increased the antioxidant capacity of CGCs exposed to ASA by promoting GPx activity (p < .05).”

“ Antioxidants that affect arachidonic acid metabolism enhance this differentiation program.”

“The thiol antioxidant NAC reduces activation of cPLA2 (assessed by isoform gel-shift and membrane translocation), production of AA in AGE-albumin–exposed neutrophils (H3 release reduced to 104±17%, P =0.94 compared with albumin-exposed neutrophils), and the AGE-augmented neutrophil respiratory burst.”

“Lipid peroxidation was induced in the E47 cells exposed to Fe plus arachidonic acid and the synergistic toxicity was prevented by antioxidants , which also decreased lipid peroxidation.”

“Results of this study, as well as those of our earlier studies, suggest that antioxidants and iron chelators prevent arachidonic acid metabolism and alter platelet function by interfering with the heme/arachidonic acid interaction and blocking cyclooxygenase metabolites essential for the formation of thromboxane A2, a potent platelet agonist.”

“However, in the aorta, antioxidant treatment in obese rats significantly reduced the increase in C16:0 and C16:l (p < 0.05 andp < 0.01, respectively) and the decrease in arachidonic acid (p < 0.05).”