Possible Interaction: Antioxidants and Apigenin

“ Apigenin , baicalein, and catechin mainly reduces blood glucose via anti-oxidation ; hesperidin is good for diabetic neuropathy; glycyrrhiza flavonoids have a significant effect on gestational DM; quercetin takes advantage of crossing the blood-brain barrier and improving renal function.”

“In summary, our results suggest that API possesses great potential to protect against AGEs-associated health disorders by modulating cellular inflammatory and antioxidant defense signaling pathways.”

“Likewise, apigenin enhanced expression of the cellular anti-oxidants SOD , CAT, and GSH-Px, but inhibited production of MDA, an oxidative stress biomarker.”

“Research results showed that vitexin and apigenin could significantly reduce the degree of hemolysis, lower MDA content, and enhance the activities of erythrocyte antioxidant enzymes.”

“Also, apigenin reduced the generation of malondialdehyde and enhanced antioxidant enzymes activities in the kidney homogenate of rats.”

“… apigenin promoted activities of enzymes … glutathione peroxidase for antioxidation and those for aerobic respiration such as mitochondrial respiratory enzyme complexes I, II, and IV, increased ATP, and enhanced expression … proliferator-activated receptor-γ coactivator 1α, mitochondrial transcription factor A, nuclear respiratory factor-1, and ATP5B involved in mitochondrial biogenesis.”

“It is concluded that apigenin prevents ISO‐induced antioxidants depletion, oxidative DNA damage, inflammatory, and apoptotic signaling in H9C2 cells.”

“The results showed that apigenin treatment (10 µM) prevented ISO (31.25 μM)‐induced lipid peroxidative levels and antioxidants status in H9C2 cells.”

“ API significantly improved the antioxidant machinery , reduced ROS levels and prevented the activation of the stress kinases, inhibitor of kappa B kinase beta (IKKβ) and c-Jun NH2 terminal kinase (JNK), and the nuclear translocation and activation of nuclear factor kappa B (NF-κB).”

“Collectively, API exerts its neuroprotective effect likely through the dual activities of anti-oxidation and anti-apoptosis, at least partly.”

“The present study thus concludes that apigenin might have inhibited oral carcinogenesis by improving the status of antioxidant defense mechanism and modulated the activities of phase I and phase II detoxification cascade toward increased excretion of active metabolite of DMBA, during DMBA induced hamster buccal pouch carcinogenesis.”