Possible Interaction: Antioxidants and Andrographolide

“ Andrographolide increased the rate of nuclear translocation of nuclear factor erythroid 2-related 2 (Nrf2) and induced antioxidant response element-luciferase reporter activity.”

“ Andrographolide thus, can play a beneficial role in modulating antioxidant defense in oxidative stress induced diseases such as diabetes, ageing etc.”

“Our findings revealed for the first time that andrographolide simultaneously upregulated antioxidant defense through the p62‐Nrf2 loop and moderately induced apoptosis through impairment of autophagic flux in CSE‐exposed bronchial epithelium.”

“ Andro enhanced Nrf2 nuclear translocation and increased the expression of Nrf2 downstream antioxidant genes both in vitro and in vivo.”

“ AG and NA increased the level of hepatic antioxidant enzymes such as superoxide dismutase (SOD), and catalase (CAT), and the level of reduced glutathione (GSH).”

“In this study, we investigated the pharmacokinetics and bioavailability of andrographolide in rats and studied whether andrographolide enhances antioxidant defense in a variety of tissues and protects against carbon tetrachloride-induced oxidative damage.”

“The 12-O-tetradecanoylphorbo-13-acetate response element or the antioxidant response element may be involved in the transactivating actions of andrographolide on the GCLC and GCLM promoters.”

“This study indicated that the diets supplemented with low-dose andrographolide (75 and 150 mg/kg) significantly improved growth performance, enhanced antioxidant capacity and regulated the intestinal physical barrier and microbiota of M. albus.”