Possible Interaction: Antioxidants and Alpha-lipoic acid

“ LA supplementation significantly reduced TBARS, AOPP and improved TAS levels in healthy subjects, while there were no significant differences in patients group.”

“In addition, LA regulated the expression levels of antioxidant proteins in a dose- and periodical time-dependent manner, which might be mediated by ERK/Akt pathway activation and independent from the mutant hSOD1 gene.”

“Our observations suggest that LA exerts strong and positive antioxidant and neuroprotective effects through the activation of the ERK-Akt pathway in hSOD1 ALS models.”

“Both classical analgesics (nonsteroidal … or carbamazepine and α-lipoic acid … antioxidant processes in the mammalian tissues and these properties of drugs such as indomethacin, meloxicam, tenoxicam, valdecoxib or some metabolites of … drug-related toxic effects, including gastrointestinal ulcers, hepatic failure, agranulocytosis, aplastic anemia, neutropenia, opiate-induced hyperalgesia and tolerance.”

“In several studies, the synergism between alpha-lipoic acid and vitamin E has been described and potent antioxidant effects can be obtained when both antioxidants are simultaneously used.”

“Along with its reduced form dihydrolipoic acid (DHLA), LA reduces and recycles cellular antioxidants such as glutathione, and chelates zinc, copper and other transition metal ions in addition to heavy metals.”

“Recent investigations have demonstrated that the combination of exercise training and antioxidant treatment using ALA in an animal model of obesity-associated insulin resistance provides a unique interactive effect resulting in a greater improvement in insulin action on skeletal muscle glucose transport than either intervention individually.”

“ALA can increase human host defense against SARS-CoV-2 by increasing intracellular pH. ALA treatment increases antioxidant levels and reduces oxidative stress.”

“An antioxidant diet significantly improved endothelial dysfunction when supplemented with alpha-lipoic acid , unlike diet with placebo or controls.”

“Furthermore it was confirmed that ALA and PFD activate diverse antioxidants mediators, however MEN decreases this response.”

“Furthermore, many studies have reported α-lipoic acid can regulate the transcription of genes associated with anti-oxidant and anti-inflammatory pathways.”