Possible Interaction: Antioxidants and 3-Nitrotyrosine

“ Antioxidants including seleno-l-methionine and superoxide dismutase mimetic (MnTBAP) as well as ERK1/2 inhibitor PD98059 effectively blocked the promoting effect of nitrotyrosine on AoSMC migration and the mRNA expression of above cell migration-related molecules.”

“Here, the authors demonstrate that copper activates the transcription factor NF-kappaB in the liver … by oxidative stress, since all copper-induced changes, which include histological alterations, formation of nitrotyrosines , vascular pressure drop, production of tumor necrosis factor-alpha (… prevented by pretreatment of the animals with the antioxidant tempol.”

“Pretreatment of cultures with α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole propionic acid (AMPA)/kainate receptor antagonist, NO‐suppressing agent, and antioxidant protected the immunoreactivity for NT or TUNEL.”

“Exposure to restraint significantly decreased hepatic concentrations of total cysteine thiols and the antioxidant reduced glutathione on Day 1 and increased 3-nitrotyrosinated and carbonylated proteins on Day 3, suggestive of oxidative/nitrosative stress in the liver following stress exposure.”

“The presence of protein-bound nitrotyrosine can be considered an indicator of a loss in the natural balance of oxidants and antioxidants , and as such, there is an emerging view that protein-bound nitrotyrosine may be a risk factor for cardiovascular disease.”