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“The lowered concentration of pyridoxal phosphate in the infested … of the possibility of two combined mechanisms: (a) an antimetabolite being secreted by the infesting worms … that partially inhibited the phosphorylation of pyridoxal , and (b) concentration of pyridoxal phosphate by the worms, … concentration of the cofactor in the host tissue.”
“Effective inhibition by the antimetabolite may be obtained at concentrations as low as 5.4 × 10−6 M. The inhibition can be overcome by adenine, adenosine, hypoxanthine, thiamine, or pyridoxine.”