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“This model can thus provide some help in devising more effective antimetabolite combinations to block the folate pathways, and in identifying the control points of this area of metabolism.”
Archives of biochemistry and biophysics • 1973 | View Paper
“Combinations of a CDK4/6 inhibitor with nucleoside or folate antimetabolites potently enhanced drug efficacy, resulting in highly synergic drug combinations (CI < 0.04).”