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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Antimalarials
supplement:
Glutathione
Research Papers that Mention the Interaction
“These results suggest a role for glutathione in the therapeutic failure to antimalarials.”
Amodiaquine failure associated with erythrocytic glutathione in Plasmodium falciparum malaria“Since the antimalarial action of the drug is antagonised by glutathione and ascorbate and has unusual pharmacokinetic properties in humans, we have investigated if the drug is broken down by a typical reductive reaction in the presence of glutathione transferases.”
“One current proposal suggests that toxic heme molecules are degraded by glutathione (GSH), and that anti-malarial drugs , such as chloroquine (CQ), inhibit this degradation, thus implicating GSH in drug resistance.”
Plasmodium berghei: analysis of the gamma-glutamylcysteine synthetase gene in drug-resistant lines.
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