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“Since the antimalarial action of the drug is antagonised by glutathione and ascorbate and has unusual pharmacokinetic properties in humans, we have investigated if the drug is broken down by a typical reductive reaction in the presence of glutathione transferases.”
“One current proposal suggests that toxic heme molecules are degraded by glutathione (GSH), and that anti-malarial drugs , such as chloroquine (CQ), inhibit this degradation, thus implicating GSH in drug resistance.”