Possible Interaction: Antimalarials and Glutathione

“These results suggest a role for glutathione in the therapeutic failure to antimalarials.”

“Since the antimalarial action of the drug is antagonised by glutathione and ascorbate and has unusual pharmacokinetic properties in humans, we have investigated if the drug is broken down by a typical reductive reaction in the presence of glutathione transferases.”

“One current proposal suggests that toxic heme molecules are degraded by glutathione (GSH), and that anti-malarial drugs , such as chloroquine (CQ), inhibit this degradation, thus implicating GSH in drug resistance.”