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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Antimalarials and Folate

supplement:

Folate

Research Papers that Mention the Interaction

Folate antagonizes the antimalarial action of sulfadoxine-pyrimethamine (SP) in vitro, but its role in vivo is not well understood.
The American journal of tropical medicine and hygiene  •  2005  |  View Paper
A majority felt that folate supplementation was a less likely cause of the Pemba result; two mentioned the interference of oral folate with antifolate antimalarials ; a majority suggested suspension of folic acid supplementation to children in malarious areas.
Food and nutrition bulletin  •  2007  |  View Paper
Antifolate antimalarial drugs interfere with folate metabolism, a pathway essential to malaria parasite survival.
Pharmacological Reviews  •  2005  |  View Paper
De novo folate biosynthesis is required for the growth of malarial parasites and is inhibited by several important antimalarial agents.
Molecular and biochemical parasitology  •  1992  |  View Paper
The clinician is also vitally concerned with folic acid because of its relationship to the megaloblastic anaemias and because a number of drugs, such as anti-malarials and anticonvulsants, are also folate antagonists.
British journal of haematology  •  1968  |  View Paper
Resistance to antimalarials targeting the folate pathway is widespread.
Molecular microbiology  •  2013  |  View Paper