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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Antimalarials
supplement:
Folate
Research Papers that Mention the Interaction
“ Folate antagonizes the antimalarial action of sulfadoxine-pyrimethamine (SP) in vitro, but its role in vivo is not well understood.”
Blood folate concentrations and in vivo sulfadoxine-pyrimethamine failure in Malawian children with uncomplicated Plasmodium falciparum malaria.“A majority felt that folate supplementation was a less likely cause of the Pemba result; two mentioned the interference of oral folate with antifolate antimalarials ; a majority suggested suspension of folic acid supplementation to children in malarious areas.”
“ Antifolate antimalarial drugs interfere with folate metabolism, a pathway essential to malaria parasite survival.”
“De novo folate biosynthesis is required for the growth of malarial parasites and is inhibited by several important antimalarial agents.”
“The clinician is also vitally concerned with folic acid because of its relationship to the megaloblastic anaemias and because a number of drugs, such as anti-malarials and anticonvulsants, are also folate antagonists.”
“Resistance to antimalarials targeting the folate pathway is widespread.”
Direct evidence for the adaptive role of copy number variation on antifolate susceptibility in Plasmodium falciparum
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