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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Antimalarials
supplement:
Antioxidants
Research Papers that Mention the Interaction
“Lastly, as important anti-malarials either increase oxidant stress or impair antioxidant defense , results may encourage the inclusion of anti-HSP molecules in anti-malarial combined drugs.”
Co-ordinated stage-dependent enhancement of Plasmodium falciparum antioxidant enzymes and heat shock protein expression in parasites growing in oxidatively stressed or G6PD-deficient red blood cells“This indicates that TryP-dependent resistance is not due to sequestration of Sb(III) and suggests that enhanced antioxidant defenses may well be a key feature of mechanisms of clinical resistance to antimonial drugs.”
“For instance, pfmdr1 gene amplification has been associated with resistance to quinine derivatives and several genes involved in anti-oxidant defence may play an important role in resistance to antimalarial drugs , although their potential involvement has been overlooked.”
“Significant augmentation in erythrocyte antioxidant status (GSH, SOD, catalase and GPx) were also observed after treatment with antimalarials.”
“ Antioxidant supplements like Vitamin C, Vitamin E and GHS may be used with anti malarial therapy ,as a preventive measure because malaria affects the secondary antioxidant defense system of the body.”
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