Possible Interaction: Antihypertensive Agents and Potassium

“Concomitant to salt reduction, potassium intake by higher intake of fruits and vegetables should be optimised, since several studies have provided evidence that potassium rich diets or interventions with potassium can lower blood pressure, especially in hypertensives.”

“In hypertensive patients treated with drugs sodium restriction and potassium and magnesium supplementation enhance the therapeutic effect, reduce the number and dosage, and lessen the adverse effects of prescribed antihypertensive drugs.”

“Lower potassium was associated with longer QT intervals (-2.8 ms; 99.75% CI: -3.5 to -2.0), JT, QRS, and PR durations, but all potassium associations were driven by use of antihypertensive drugs.”

“In hypertensives , weight reduction, limitation of alcohol and sodium intake, and increasing potassium and magnesium intakes have a demonstrable effect.”

“Thus hypertensives with decreased aldosterone responsiveness to infused All also had decreased responsiveness to infused ACTH and potassium , suggesting that their defect lies in the intracellular aldonterone blosynthetic pathway.”

“The reduced expression of angiotensin-I converting enzyme, renin, and angiotensin converting enzyme 2 during potassium supplementation suggest that high dietary potassium intake could modulate these vasoactive enzymes and this effects can contribute to the preventive and antihypertensive effect of potassium.”