Possible Interaction: Antihypertensive Agents and Glucose

“ Antihypertensive drugs , recommended by the World Health Organization for use in monotherapy, exert different effects on glucose and lipid metabolism.”

“Dear Sir: Some antihypertensive drugs have been shown to induce untoward side effects on glucose and lipid metabolism that may accelerate the early development of arteriosclerotic lesions.”

“The harmful metabolic effects of some hypotensive agents on serum potassium, magnesium, uric acid, glucose , renin and lipids might reduce the beneficial effect of controlling raised blood pressure.”

“Similarly, plasma levels of glucose , blood urea nitrogen (BUN) and creatinine, but not insulin, were significantly (P<0.05) higher among hypertensives than normotensives.”

“The response to glucose load was significantly higher in the hypertensives than normotensives particularly at 2 hours p < 0.001.”

“On the other hand, older hypertensive patients have greater reductions in blood pressure levels after a meal or after oral glucose ingestion than do age matched normotensive people.”

“Although no significant differences in systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting … UAE were observed among genotypes at the initial examination, during the 3 years of antihypertensive treatment the slope … the DBP, fasting glucose and UAE differed significantly despite no differences … the distribution of treatments being present.”

“SBP, DBP, PP and the use of antihypertensive drugs increased along with the deterioration of glucose status.”

“In contrast, heart glucose uptake was 33% increased in the hypertensives (939 +/- 51 vs 707 +/- 46 mumol/kg muscle per min, P < 0.005), and correlated with systolic blood pressure (r = 0.66, P < 0.001) and the minute work index (r = 0.48, P < 0.05).”

“ Older hypertensive persons have greater reductions in blood pressure after ingesting food or oral glucose than do age-matched normotensive persons [7, 9, 10, 17-20].”