Possible Interaction: Antihypertensive Agents and Epinephrine

“3) The levels of plasma SP increased and the concentrations of NA and AD decreased after antihypertensive drug treatment.”

“The hormonal pattern was normal except for noradrenaline values that were twofold above the normal range (966 pg/ml), and a slight increase in the values of adrenaline (268 pg/ml) while antihypertensive treatment was given.”

“Graded adrenaline infusion had no effect on atrial natriuretic peptide levels in the controls but significantly raised atrial natriuretic peptide levels in the hypertensives.”

“In contrast to NTs, stress in HTs significantly increased urinary excretion of epinephrine and norepinephrine, whereas exercise failed to increase urinary catecholamine excretion in both groups.”

“Both resting and stimulated (straight‐leg raising and head‐up tilt) levels of arterial and venous plasma noradrenaline were significantly higher during low‐dose adrenaline infusion in five mild hypertensive and four normotensive patients with one adrenal.”

“Urinary excretion of adrenaline was somewhat lower in the hypertensives than in the controls.”

“Activation of Na+, K+ pumps using adrenaline or insulin produces a significantly smaller hyperpolarization in hypertensive soleus than in control muscles.”

“Circulating AD did not differ between the normotensive strains but was 3-4 times higher in the hypertensive strains.”

“Conclusions: Perineural epinephrine for brachial plexus blockade does not reduce hypotension due to dexmedetomidine infusion and may actually augment the occurrence of hypotensive events.”

“the drug lowered blood pressure and reduced the pressor effects to epinephrine and norepinephrine.”