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Last Updated: 3 years ago

Possible Interaction: Antidepressive Agents and Oxytocin

Research Papers that Mention the Interaction

A distinct pattern of higher levels of OT in depressed Latinas suggests that OT levels may be an important neuroendocrine factor contributing to depressive and anxious symptoms.
Archives of Women's Mental Health  •  2018  |  View Paper
Higher synOT dose was associated with greater depressive , anxious, and somatization symptoms.
Birth  •  2016  |  View Paper
Secretion of oxytocin , an appetite-regulating neurohormone with anxiolytic and antidepressant properties, is abnormal in AN.
The Journal of clinical psychiatry  •  2016  |  View Paper
OT may mediate the antidepressant effects of mating behavior.
Neuroscience Research  •  2010  |  View Paper
Besides, we summarize the mechanisms by which the oxytocin system exerts potential antidepressant effects, including regulating neuronal activity, influencing neuroplasticity and regeneration, altering neurotransmitter release, down regulating hypothalamic–pituitary–adrenal axis, anti-inflammatory, antioxidation, and genetic effects.
Reviews in the neurosciences  •  2021  |  View Paper
However, oxytocin blood concentrations increased more steeply in those on antidepressants across the perinatal period compared to control women.
In conclusion, although antidepressant use and oxytocin was not associated at any time point, women taking antidepressants during pregnancy had larger increases in oxytocin over the perinatal period.
Progress in Neuro-Psychopharmacology and Biological Psychiatry  •  2021  |  View Paper