Possible Interaction: Antidepressive Agents and Levomefolate

“Augmentation of SSRI and SNRI antidepressant medications with l-methylfolate has been demonstrated to increase their effectiveness and onset of action.”

“Even the use of l-methylfolate as a stand-alone monotherapy has been observed to exert antidepressant properties.”

“Using a placebo-controlled, nonparallel group study design with only 75 patients and 6 sites, these investigators detected significant augmentation of AD treatment with methylfolate (mean pooled drug-placebo difference, 2.54; P <0.05, Cohen d = 0.385).”

“Antidepressant effects have been reported when antidepressants are augmented with folic acid, folinic acid, or the centrally active L-methylfolate (known formally as (6(S)-5-methyltetrahydrofolate [MTHF]), particularly in depressed patients with folate deficiency whose major depressive episodes have failed to respond to antidepressants.”