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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glycine
Research Papers that Mention the Interaction
“Results showed that when combined with GLY, ADS whose main pharmacological effect is one of 5-HT uptake blockade (imipramine, amitriptyline, citalopram, paroxetine, fluoxetine, and fluvoxamine) were more effective in decreasing the amount of time mice were immobile, than when these drugs were administered alone.”
“Some noradrenaline uptake inhibiting ADS (desipramine and viloxazine, but not maprotiline) were also significantly more effective in decreasing immobility time when combined with GLY than when administered alone.”
“Abstract: We have previously demonstrated that chronic administration of antidepressants results in a reduction in the potency of glycine to displace 5,7‐[3H]dichlorokynurenic acid (5,7‐[3H]‐DCKA) from the strychnine‐insensitive glycine recognition site of the NMDA receptor complex.”
“Chronic (14 day) but not acute (1 day) treatment of mice with clinically active antidepressants produces a significant (approximately 1.8-4.3 fold) reduction in the potency of glycine to inhibit [3H]-5,7-dichlorkynurenic acid (5,7-DCKA) binding to strychnine-insensitive glycine receptors in neocortical membranes.”
Adaptation of the N-methyl-D-aspartate receptor complex following chronic antidepressant treatments.
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