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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glutathione
Research Papers that Mention the Interaction
“In addition, chronic treatment with other mood stabilizing drugs lamotrigine and carbamazepine, but not antidepressants desipramine and fluoxetine, increased both glutathione levels and the expression of glutamate-cysteine ligase in SH-SY5Y cells.”
Role of glutathione in neuroprotective effects of mood stabilizing drugs lithium and valproate“The antidepressants caused increases in intracellular GSH in the C6 cells at subcytotoxic concentrations, with decreases in GSH occurring at higher concentrations.”
“Furthermore, the combined treatment of sub-effective doses of GSH (100 nmol/site, icv) with a sub-effective dose of classical antidepressants (fluoxetine 10 mg/kg, and imipramine 5 mg/kg, ip) presented synergistic effect by decreasing the immobility time in the FST.”
Multiple cellular targets involved in the antidepressant-like effect of glutathione.
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