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Last Updated: 2 years ago

Possible Interaction: Antidepressive Agents and Gamma-Aminobutyric Acid

Research Papers that Mention the Interaction

Finally, we discuss the connections between serotonergic and GABAergic neurotransmission, and show that two serotonin-focused antidepressants – the selective serotonin-reuptake inhibitor fluoxetine and the multimodal antidepressant vortioxetine – modulate GABA neurotransmission in opposing ways, despite both being effective MDD treatments.
Drug design, development and therapy  •  2015  |  View Paper
Our data in combination with previous ones from other laboratories suggest that antidepressants suppress the activity of presynaptic 5-hydroxytryptamine3 receptors on GABA neurons, resulting in the reduction of GABA release.
We reviewed possible involvement of gamma-aminobutyric acid (GABA)B receptors in action of antidepressants.
Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology  •  2003  |  View Paper
Anxiogenic agents augment norepinephrine activity, some anxiolytics increase serotonin neurotransmission while benzodiazepines and antidepressants influence catecholamine, indoleamine and gamma-aminobutyric acid turnover in infrahuman subjects.
Progress in Neurobiology  •  1995  |  View Paper
Background: Previous studies have demonstrated that antidepressant medication and electroconvulsive therapy increase occipital cortical γ-aminobutyric acid (GABA) in major depressive disorder (MDD), but a small pilot study failed to show a similar effect of cognitive-behavioral therapy (CBT) on occipital GABA.
Psychotherapy and Psychosomatics  •  2014  |  View Paper
Since recent neuroimaging studies have demonstrated that antidepressants modulate GABA levels, additional experiments were performed to examine the levels of GAD in eight depressed subjects treated with antidepressant medications.
The international journal of neuropsychopharmacology  •  2010  |  View Paper
Pregabalin is a new synthetic molecule and a structural derivative of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), while it … partial onset seizures as well as for fibromyalgia that is commonly comorbid with depressive disorders.(Pae et al., 2008) Antidepressants … GABA levels but also ameliorate … (Lodge and Li, 2008).
Progress in Neuro-Psychopharmacology and Biological Psychiatry  •  2009  |  View Paper
In support of these observations, we review data from animal models of epilepsy showing that decreased activity of serotonin, norepinephrine, dopamine, and GABA facilitate the kindling process of seizure foci, worsen seizure frequency and severity, and are reversed or blocked by antidepressant drugs.
Neurology  •  2002  |  View Paper
We recently discovered that rapid antidepressants cause a shift in the γ-aminobutyric acid receptor (GABABR) signaling pathway, such that GABABR activation shifts from opening inwardly rectifiying potassium channels (Kir/GIRK) to increasing resting dendritic calcium signal and mammalian Target of Rapamycin activity.
Molecular Psychiatry  •  2015  |  View Paper
A widely used antidepressant drug , however, increased GABA co-release.
Science  •  2014  |  View Paper
Since antidepressants have been reported to inhibit GABA uptake, we examined those effects on mouse BGT1 (mBGT1) in comparison with other mouse GAT (mGAT) subtypes in the heterologously expressed cell cultures.
International journal of molecular sciences  •  2012  |  View Paper
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