Possible Interaction: Antidepressive Agents and Fatty Acids, Omega-3

“BACKGROUND Extant literature shows that adjuvant omega-3-polyunsaturated fatty acids (O3PUFAs) to a standard antidepressant medication impacts favorably on symptoms of depression in participants with major depressive disorders (MDD).”

“Nutritional supplements such as omega-3 have been found to produce beneficial effects in the management of treatment-resistant depression when administered in combination with the ongoing antidepressant treatment.”

“Pilot studies in unipolar depression report an improvement in depression when omega-3 fatty acids are given with antidepressants.”

“Nevertheless, adjunctive prescription of omega-3 with antidepressants , or in people with dietary deficiency, may be beneficial.”

“CONTEXT Studies of depressed psychiatric patients have shown that antidepressant efficacy can be increased by augmentation with omega-3 fatty acids.”

“We previously reported that combined fluoxetine administration at antidepressant doses renders additive antidepressant effects, whereas non-antidepressant doses potentiate the omega-3 fatty acid antidepressant effect.”

“Beneficial effects of combined treatment were also observed at sub-effective doses (1 mg/kg/day) of fluoxetine or mirtazapine, since in combination with omega-3 fatty acids (720 mg/kg/day), antidepressants potentiated omega-3 antidepressant-like effects.”

“ LCn-3 fatty acid supplementation has been shown to augment the therapeutic efficacy of antidepressant , mood-stabilizer, and second generation antipsychotic medications, and may additionally mitigate adverse cardiometabolic side-effects.”