Possible Interaction: Antidepressive Agents and Dextroamphetamine

“ d-Amphetamine was 2 to 2.3-fold more effective in producing activation, euphoria, and antidepressant effects than the same dose of l-amphetamine.”

“A study of 12 depressed inpatients shows a significant correlation of improvement with both double-blind administration of dextroamphetamine sulfate and tricyclic antidepressant drug treatment and the l ow mean baseline excretion of 3-methoxy-4-hydroxyphenylglycol (MHPG).”

“A few AD (including citalopram, a selective inhibitor of the 5-HT uptake), administered repeatedly, potentiate the locomotor hyperactivity induced by D-amphetamine or apomorphine, without affecting the stereotypy evoked by both dopaminomimetics.”

“ d-Amphetamine together with CNS depressants produced a greater effect than amphetamine alone.”

“It had previously been shown that repeated administration of antidepressants with different pharmacological profiles enhanced the action of D-amphetamine , quinpirole and other dopamine stimulants.”

“Only the repeated administration of antidepressant drugs enhanced the locomotor hyperactivity induced by D-amphetamine.”

“Such a difference in … time-dependent effects of antidepressant drugs on the locomotor activity induced by either the low dose of apomorphine or D-amphetamine may possibly result from the different mechanisms involved in the regulation of the biosynthesis of dopamine presynaptic and postsynaptic receptors in the rat brain.”

“In other experiments it was found that chronic administration of some (amitryptyline, imipramine, mianserin, iprindole) but not all (zimelidine, nomifensine, fluoxetine) antidepressants enhanced the locomotor response to d-amphetamine.”

“Abstract The rotarod disruption in rats by 1.5 g/kg of ethanol was prolonged by combining the depressant with 2 or 8 mg/kg d-amphetamine , but not after combinations with 4 or 6 mg/kg of the stimulant.”

“The data also suggest that, to achieve anorexia with diminished CNS stimulation, combinations of d-amphetamine and any of the tested CNS depressants seem to be precluded.”

“Abstract Several reports in the literature have indicated that antidepressants such as amitriptyline and impramine potentiate the effects of d-amphetamine on conditioned avoidance responses, and also enhance pharmacological actions demonstrated in other tests (1,2,3).”